Drug discovery and Multiorgan Damage in Covid-19. Podcast with Ernesto Estrada about biochemistry, potential drugs and pharmaceutical targets (Part 2).

There are three parts of various topics with Ernesto. Watch all of them, share and enjoy.

Podcast host Prof. Jan Nagler (Head of Deep Dynamics Group),
https://sites.google.com/view/deep-dy...
in conversation with chemist, biochemist, network scientist
and mathematician Prof. Ernesto Estrada,
https://en.wikipedia.org/wiki/Ernesto...

Acknowledges, sources, and credits:

Paper: How does coronavirus kill? Science, April 2020:
https://www.sciencemag.org/news/2020/04/how-does-coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-brain-toes

Virus structure, An atom-by-atom model of the coronavirus,
Lorenzo Casalino and Abigail Dommer, Amaro Lab, U.C. San Diego
Spike Proteins and their flexibility, A simulation of four spike proteins, each bending on three hinges.
Sören von Bülow, Mateusz Sikora and Gerhard Hummer, Max Planck Institute of Biophysics
Article , New York Times:
https://www.nytimes.com/interactive/2020/health/coronavirus-unveiled.html?smid=tw-share

Long Covid: When coronavirus symptoms don't go away | DW News, Dec 13, 2020:
https://www.youtube.com/watch?v=J27XLSI5M-Q

Cytokine storm, Beckman Coulter Dx
What is a Cytokine Storm and How Does it Impact COVID-19 Patients?
https://www.youtube.com/watch?v=b9J3NjvDIQA

DW: How does coronavirus attack your body? | COVID-19 Special, Dec 8 2020:
https://www.youtube.com/watch?v=tq0vzPOomrU

https://www.longcovid.org/

Ventilator vs ECMO:
https://www.youtube.com/watch?v=MwotQDLAUw4

Cytokine elevation in severe and critical COVID-19: a rapid
systematic review, meta-analysis, and comparison with
other inflammatory syndromes
www.thelancet.com/respir atory Vol 8 December 2020

Ulimate Chain Reaction created by 2014 mousetraps and 2015 Ping pong balls, BuzzV Viral Videos:
https://www.youtube.com/watch?v=nM-_XaBVneE

A repository of assays to quantify 10,000 human proteins by SWATH-MS,
George Rosenberger et al, Nature Sc. data,
https://www.nature.com/articles/sdata201431

Hormones and Irregular Heartbeats: What's the Connection? credit: Banner Health
https://www.youtube.com/watch?v=k_kUEyfVmTU

TED-Ed: How do your hormones work? Emma Bryce:
https://www.youtube.com/watch?v=-SPRPkLoKp8

Ch 17: Hormone transport, StudentHelp4AP:
https://www.youtube.com/watch?v=a4OrZcUtI9c

Extracellular Vesicles - the cells' secret messengers - Scientific version, Arkitek Scientific:
https://www.youtube.com/watch?v=OQeRfaQkZCk

Exosomes - rethinking drug delivery, Phospho Biomedical Animation
https://www.youtube.com/watch?v=9UMOV3tvFuk

Protein-protein binding pathway using fully-continuous, explicit-solvent simulations, Chong Lab Science:
https://www.youtube.com/watch?v=0mhMwpLSUXY

Protein protein interaction, Shomu's Biology (famous channel in India):
https://www.youtube.com/watch?v=hS5cRDU_8CM

Network-based prediction of protein interactions
István A. Kovács et al,
Nature Communications volume 10, Article number: 1240 (2019)

Parkinson paper:
https://www.thelancet.com/action/showPdf?pii=S1474-4422%2820%2930305-7
(only n=1 case!) and study also the comment as shown in the podcast.

Long term effects and damage in covid-19:
https://www.nature.com/articles/d41586-020-02598-6
https://www.sheffield.ac.uk/news/hidden-damage-lungs-covid-19-revealed-new-study-university-sheffield
Multi-organ impairment in low-risk individuals with long COVID,
https://www.medrxiv.org/content/10.1101/2020.10.14.20212555v1.full.pdf
https://www.bmj.com/content/371/bmj.m4470
The Long-Term Effects of COVID-19, The Cura Foundation,
https://www.youtube.com/watch?v=qXRdaHdtoFc

Shown movie: Documenting long-term effects of COVID-19, UW Medicine (Oct 6 2020):
https://www.youtube.com/watch?v=HbtQVa6fUjM

Drug repurposing, paper:
David E. Gordon, Gwendolyn M. Jang, […] Nevan J. Krogan
Nature volume 583, pages459–468(2020)
https://www.nature.com/articles/s41586-020-2286-9

Ernesto Estrada, Protein-Driven Mechanism of Multiorgan Damage in COVID-19:
https://www.sciencedirect.com/science/article/pii/S2590098620300567

Diffusion and Crowding inside the Cell - ETHZ & ScienceVisuals/Visualbiotech, Sciencevisuals:
https://www.youtube.com/watch?v=R-wAt7LFDMs

Marcelo Merello Kailash P Bhatia Jose A Obeso, Lancet
SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30442-7/fulltext

HIV Protease Action, RCSBProteinDataBank:
https://www.youtube.com/watch?v=dDo_s6a3wcM

Nature Paper: Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors,
Zhenming Jin et al, Nature volume 582, pages289–293(2020)
https://www.nature.com/articles/s41586-020-2223-y

Media Coverage, Protease, News medical life science:
https://www.news-medical.net/news/20200609/Protease-inhibition-could-help-defeat-SARS-CoV-2.aspx